Getting to Uganda from Kisii is an easy affair. This will apply when you intend on using the Busia Border point to cross over to Uganda. You can choose to do direct travel i.e. via a bus, currently the Akamba Bus Services is the only bus company offering direct connection to Uganda, Kampala from Kisii. Alternatively you can choose to do connections that is you will travel in splits e.g. you can board a matatu to Kisumu and then board a bus to Kampala(in Kisumu you have multiple buses connecting to Kampala) or board a matatu to Busia from Kisii. A third option is to board a matatu from Kisii to Kericho town where you can get a variety of buses from Mombasa and Nairobi going to Kampala via Kisumu city. At the Busia border point you will need a pass/permit/passport to exit Kenya and enter Uganda. You can apply for a temporary permit at the border point at a minimal cost within a few minutes.